Gene Expression and Genetics
I want to talk about my genetics now and what is going wrong at the cellular level. In 2023, I underwent genetic testing to find out if my muscles are mutated. The results were successful, and we were able to determine precisely what gene is mutated. The photo below is from the letter I received from my specialist in the area. It tells the exact coordinates of the mutation on my chromosomes. Chromosome 2 to be exact.
My Intrinsic Flaw
It is worth mentioning that I have two copies of chromosome 2 and only one of those copies is mutated. Chromosomes encode proteins, and any flaw in a chromosome is expressed in the protein that it encodes. The proteins that my mutation encodes are acetylcholine receptors that experience prolonged activation from acetylcholine binding too long. To understand how this affects me, you have to understand how muscles move normally. Then we will be able to understand how I move abdnormally. After which, we will be able to understand how I have been improving.
The Normal Physiology of Muscle Contraction
Acetylcholine (aCh) is a neurotransmitter released in the nervous system to communicate between separate neurons, and it is also found at the neuromuscular junction, which is where motor neurons connect to skeletal muscle. Vesicles, which are like little bubbles full of stuff in a cell, are pushed out of neurons releasing their contents into the neuromuscular synaptic clef (the space between a neuron and a muscle cell). The aCh is released and floats across the synaptic clef where it binds to a specific receptor that causes a channel to open in the muscle cell allowing sodium (Na) to enter the cell, which then opens different channels allowing for potassium (K) to exit the cell. The shift in the concentration of these ions changes the polarization of the cell. The change in polarization leads to Calcium (Ca++) being released from structures inside the muscle cell called sarcoplasmic reticulum. The diagram below shows this process.
The calcium binds to a protein called troponin which is found on parts of muscle cells called actin. The calcium changes the shape of the troponin which exposes part of the actin which compels a different part of the muscle cell called myosin to attach the actin where it has become exposed. This process burns ATP (cellular energy). The binding of myosin to actin makes the muscle cell become shorter. This is how muscle tissue contracts.
Image credit: Daniel Walsh and Alan Sved, CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Commons (some colors were changed).
This process of contraction can go on for as long as there are adequate calcium and ATP stores.
My Abnormal Contraction
Now Imagine this picture but in a different way. Imagine that some of the aCh gets stuck in its receptor too long. There could be a few outcomes of this pathology.
- Exhaustion of Ca++ stores
- Exhaustion of ATP stores
- Abnormal contraction
- Failure to contract
- Abnormal polarization of the cell
The most important effect of this is the abnormal polarization of the sarcomere. Since there is residual Ca++ ultimately being released as one of the effects of this syndrome, if this syndrome is exacerbated enough by repeated contractions, then the muscle can actually produce a contraction with out a nerve impulse from the excess of Ca++ in the cell.
This echo is important for the reasons described in The Introduction to the fourth video. But what’s more, it shows a physiological basis for the peculiar movements that i have been undergoing for much of my life.
Part 4 The Search for God
To make the final results of The Document on My Muscles easier to access the following images are links to the introduction to part for and part 4 respectively:
Ultimately this project led to me being able to put together the video which is the concrete universality of the decisive moment in the first draft of the Ages of the World by Fredrick Schelling. If I had not made this project or read that first draft, then I would not have been able to arrive at this conclusion: my body is undergoing seemingly false impossible contraction with the same properties as the seemingly impossible contraction that theoretically God undergoes materially during the world creation. A concrete universality according to Slavoj Ziezk is a individual particular that embodies a universal.
The Word 